Promethazine is an H1 receptor blocking agent. As well as its antihistaminic action, it offers clinically valuable sedative and antiemetic effects.

Sedating medicines may well cause confusion and over-sedation from the aged; aged people commonly ought to be began on small doses of Promethazine HCl Oral Answer and noticed closely.

Promethazine need to be employed cautiously in persons with cardiovascular disease or with impairment of liver function.

The subsequent major adverse reactions are described, or explained in greater detail, in other sections:

Promethazine administered to the pregnant female inside two weeks of delivery may perhaps inhibit platelet aggregation within the newborn.

Codeine could greatly enhance the neuromuscular blocking motion of skeletal muscle mass relaxants and generate a heightened diploma of respiratory despair.

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Minimal hypertension. A unexpected drop in blood pressure can occur in many people for the duration of treatment with Promethazine Hydrochloride and Codeine Phosphate Oral Answer and this might cause you to come to feel dizzy, faint, lightheaded, or weak, specially when you stand up (orthostatic hypotension). Your possibility of having this problem can be enhanced if you take Promethazine Hydrochloride and Codeine Phosphate Oral Answer with specific other medicines that lower hypertension.

sedation, reduction of stress and anxiety, and production of light slumber from which the individual may be easily aroused

Promethazine HCl occurs being a white check here to faint yellow, pretty much odorless, crystalline powder which slowly oxidizes and turns blue on prolonged publicity to air. It is freely soluble in water and soluble in Liquor.

The impact of promethazine and/or codeine on afterwards expansion and improvement from the new child is mysterious.

Interest must be offered on the reestablishment of sufficient respiratory Trade via provision of the patent airway and establishment of assisted or controlled air flow. Diazepam may very well be employed to regulate convulsions. Acidosis and electrolyte losses ought to be corrected. Observe that any depressant outcomes of Promethazine HCl are usually not reversed by naloxone. Prevent analeptics which may trigger convulsions.

Discontinuation of the concomitantly applied cytochrome P450 2D6 inhibitor may cause a lessen in codeine plasma concentration and a rise in active metabolite morphine plasma focus which could boost or extend adverse reactions and will bring about potentially fatal respiratory despair.

Nevertheless, codeine has to be administered only underneath close supervision to people that has a historical past of drug abuse or dependence.